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Xalatan should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. While treatment with Xalatan can be continued in patients who develop noticeably increased iris pigmentation, these patients should be examined regularly. The events, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to Xalatan, or a combination of these factors, include: asthma and exacerbation of asthma; corneal edema and erosions; dyspnea; eyelash and vellus hair changes (increased length, thickness, pigmentation, and number); eyelid skin darkening; herpes keratitis; intraocular inflammation (iritis/uveitis); keratitis; macular edema, including cystoid macular edema; misdirected eyelashes sometimes resulting in eye irritation; dizziness, headache, and toxic epidermal necrolysis. Because many drugs are excreted in human milk, caution should be exercised when Xalatan is administered to a nursing woman. After discontinuation of Xalatan, pigmentation of the iris is likely to be permanent while pigmentation of the periorbital tissue and eyelash changes have been reported to be reversible in some patients.
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